NAC has traditionally been used as a treatment for an overdose of paracetamol. It has also previously been found to be beneficial for people with schizophrenia and partially effective for people with clinical depression. The Geelong scientists are trialing a treatment that involves a compound called N-acetyl cysteine, known as NAC, in combination with other potentially energy-boosting supplements. "Bipolar disorder seems to be a disorder of energy; too little in depression and too much in mania," said Professor Michael Berk, who is leading the study. "This suggests that if we can usefully target energy, we might help depression in bipolar disorder."